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Frédéric Simonin Selected Research

neuropeptide FF receptor

11/2018Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia.
1/2017RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.
3/2015Development of a peptidomimetic antagonist of neuropeptide FF receptors for the prevention of opioid-induced hyperalgesia.
1/2006RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.

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Frédéric Simonin Research Topics

Disease

12Hyperalgesia
01/2022 - 01/2006
9Pain (Aches)
01/2022 - 03/2002
5Chronic Pain
01/2022 - 01/2006
2Respiratory Insufficiency (Respiratory Failure)
09/2018 - 01/2016
2Hypersensitivity (Allergy)
01/2017 - 12/2016
1Neoplasms (Cancer)
01/2021
1Obesity
06/2017
1Neuralgia (Stump Neuralgia)
01/2016
1Sleep Wake Disorders
01/2014

Drug/Important Bio-Agent (IBA)

13Opioid Analgesics (Opioids)IBA
01/2022 - 01/2006
10Analgesics (Analgesic Drugs)IBA
10/2021 - 01/2014
5Opiate AlkaloidsIBA
11/2018 - 01/2014
5phenylalanyl- leucyl- phenylalanyl- glutaminyl- prolyl- glutaminyl- arginyl- phenylalaninamideIBA
11/2018 - 01/2006
5Morphine (MS Contin)FDA LinkGeneric
09/2018 - 12/2013
4Fentanyl (Sublimaze)FDA LinkGeneric
10/2021 - 01/2017
4neuropeptide FF receptorIBA
11/2018 - 01/2006
4AmidesIBA
01/2017 - 12/2013
4Peptides (Polypeptides)IBA
04/2016 - 12/2013
2DipeptidesIBA
10/2021 - 11/2018
2LigandsIBA
11/2018 - 01/2016
1NeuropeptidesIBA
10/2021
1Luteinizing Hormone (Lutropin)FDA LinkGeneric
10/2021
1Pharmaceutical PreparationsIBA
01/2021
1HydrazonesIBA
11/2018
1pimagedine (aminoguanidine)IBA
11/2018
1Oxycodone (Oxycontin)FDA LinkGeneric
09/2018
1Hormones (Hormone)IBA
06/2017
1morphine-3-glucuronideIBA
01/2017
1mu Opioid Receptors (mu Opioid Receptor)IBA
01/2017
1NociceptinIBA
01/2016
1OrnithineIBA
03/2015
1PeptidomimeticsIBA
03/2015
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2014
1MT1 Melatonin ReceptorIBA
01/2014
1Heroin (Diamorphine)IBA
01/2006
1Opioid Peptides (Opioid Peptide)IBA
03/2002

Therapy/Procedure

5Analgesia
01/2022 - 12/2013